On the last day of the North American CF Conference this weekend, Dr Janet Allen, Director of Strategic Innovation at the Trust, attended a session focused on 'Anti-inflammatories in CF: Pathways to Therapeutics’. This session set the scene for a wider debate around the outcomes of the Cystic Fibrosis Foundation’s working group on the topic. In her blog on the session, you can find out more about the human body’s immune response to inflammation and what this means for people with cystic fibrosis.
The question is: how do we control and fine tune our body’s inflammation response to infection?
Following an infection in the lungs, the body’s defence inflammation system responds to fight the invading bugs. The immune defence system is complex, but the primary cells recruited to start the fight are a type of white blood cell called neutrophils. These cells are not normally found in the lung, but following the detection of infection vast numbers move into the lungs from the blood and start to fight the harmful bacteria. Neutrophils are professionals and usually have all the tools they need to eat/kill the bacteria.
If they succeed, these cells do their job and then die in a very controlled way. Or, if they sense that they are losing the battle against the infection, they send out signals saying ‘We need help’. More neutrophils and other cells of the immune system are recruited, leading to further inflammation. In people with CF, it is thought that this signalling for help carries on longer than it should (the “off switch” does not function properly) and, as a result, there is more inflammation than is necessary. This additional information is thought to damage the lungs.
So, we need neutrophils to fight the infection but their very activation can lead to lung damage. There are ways of turning neutrophils ’on’ to do this job, but equally important there are signals that turn the neutrophils ‘off’. Most anti-inflammatory drugs stop the ‘on’ signals, as until recently we have understood less well the ‘off’ signals.
The dilemma is how to control the neutrophils to attack the infection and then stop without sending out ’help’ signals. This is a fine balancing act. In addition, the clinical trials to assess effectiveness will be quite long unless more sensitive measures of lung function are developed, which would enable the use of shorter trials with fewer participants than is possible using current techniques.
So, the symposium addressed some of these key questions:
The session was well attended by CF clinicians and researchers from around the world and helped stimulate discussion and focus attention on this important challenge ahead of publication of the CFF working group’s guidance. This work will inform future research and therapeutic development globally and help to ensure it is done in a way that is safe and brings maximum benefit to people with CF.
Dr Janet Allen is a member of the CFF working group which brings together leading experts in CF inflammation from around the world
The question is: how do we control and fine tune our body’s inflammation response to infection?
Following an infection in the lungs, the body’s defence inflammation system responds to fight the invading bugs. The immune defence system is complex, but the primary cells recruited to start the fight are a type of white blood cell called neutrophils. These cells are not normally found in the lung, but following the detection of infection vast numbers move into the lungs from the blood and start to fight the harmful bacteria. Neutrophils are professionals and usually have all the tools they need to eat/kill the bacteria.
If they succeed, these cells do their job and then die in a very controlled way. Or, if they sense that they are losing the battle against the infection, they send out signals saying ‘We need help’. More neutrophils and other cells of the immune system are recruited, leading to further inflammation. In people with CF, it is thought that this signalling for help carries on longer than it should (the “off switch” does not function properly) and, as a result, there is more inflammation than is necessary. This additional information is thought to damage the lungs.
So, we need neutrophils to fight the infection but their very activation can lead to lung damage. There are ways of turning neutrophils ’on’ to do this job, but equally important there are signals that turn the neutrophils ‘off’. Most anti-inflammatory drugs stop the ‘on’ signals, as until recently we have understood less well the ‘off’ signals.
The dilemma is how to control the neutrophils to attack the infection and then stop without sending out ’help’ signals. This is a fine balancing act. In addition, the clinical trials to assess effectiveness will be quite long unless more sensitive measures of lung function are developed, which would enable the use of shorter trials with fewer participants than is possible using current techniques.
So, the symposium addressed some of these key questions:
- What are the best targets/drugs to test in CF inflammation?
- How can we be sure we will not stop the neutrophils from fighting the infection?
- What can we learn from previous studies?
- How can we design clinical trials to shorten their duration and still get a clear result?
The session was well attended by CF clinicians and researchers from around the world and helped stimulate discussion and focus attention on this important challenge ahead of publication of the CFF working group’s guidance. This work will inform future research and therapeutic development globally and help to ensure it is done in a way that is safe and brings maximum benefit to people with CF.
Dr Janet Allen is a member of the CFF working group which brings together leading experts in CF inflammation from around the world
Registered Company No. 3880213
HOW DR IMOLOA HERBAL MEDICINE HELPED ME GET RID OF MY 3 YEARS HERPES SIMPLEX VIRUS. Hello everyone my name is DONALD am from the united states i have been suffering from (HERPES) disease since 2016 and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr Imoloa and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr imoloa telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Doctor assured me that i have been cured,after some time i went to my doctor to confirmed if i have been finally healed behold it was TRUE, So friends my advise is, if you have such sickness or any other at all like, FEVER, DIARRHOEA, LUPUS, DRY COUGH, MOUTH ULCER, MOUTH CANCER, EYE CANCER, ACUTE MYELOID LEUKAEMIA, KIDNEY DISEASE, EPILEPSY, FIBROID, PENILE CANCER, BOWL CANCER, SKIN CANCER, PANCREATIC CANCER, HAIRY CELL LEUKAEMIA, PENILE CANCER, JOINT PAIN, BONE CANCER, PRAKISON'S DISEASE, FATIGUE, MUSCLE ACHES, ANAL CANCER, ARTHRITIS, BREAST CANCER, BONE CANCER, HEPATITIS A,B,C,CANCER,HPV,HIV/AIDS,DIABETES 1 AND 2,SMALL PENIS PROBLEM ,HIGH BLOOD PRESSURE SYPHILIS, WEAK ERECTION,BREAST ENLARGEMENT AND many more ....... you can email him on drimolaherbalmademedicine@gmail.com) or whatsapp him on +2347081986098. Sir, i am indeed grateful for the help i will forever be grateful for the good work.
ReplyDeleteColorectal cancer, cancer of the large intestine, is the fourth most common cancer in North America. Many cases of colorectal cancer are associated with low levels of physical activity and with diets that are low in fruits and vegetables. Individuals with a family history of the disease have a higher risk. I crumble with this disease for 5 years also with a lot of scaring thought in my head because i was just waiting for death every day of my life until My Son came to me in the hospital explaining to me that he has find a herbal healer from Nigeria to cure my Colo-Rectal Cancer,I was so shocked with the ideal also i was excited inside of me.My son asked me to let us give him a try because we have really heard a lot of scammer pretending to cure all sort of diseases with herbal medicine and some of them never get a positive result at the end of it all but we was very confident on this herbal doctor,like i said we give him a try and he sent me a herbal medicine to drink for three weeks, Sincerely I'm telling you today I' alive and healthy no more laying on sick bed,No more Colo-Rectal Cancer.I'm sharing this testimony on here for people who are sick to contact this Wonderful man,His name is Dr Itua.And His contact Whatsapp_+2348149277967____Email... drituaherbalcenter@gmail.com.He can cure those diseases like:Bladder cancerBreast cancerColorectal cancerKidney cancerLeukemiaLung cancerNon-Hodgkin lymphomaProstate cancerSkin cancerUterine cancerParkinson's,Alzheimer’s disease,Bechet’s disease,Crohn’s disease
ReplyDelete,Cushing’s disease,Heart failure,Multiple Sclerosis,Hypertension,Colo_Rectal Cancer,Lyme Disease,Blood Cancer,Brain Cancer,Breast Cancer,Lung Cancer,Kidney Cancer, Spell,Stroke,Lottery Spell,disease,Schizophrenia,Cancer,Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity Syndrome Fibrodysplasia Ossificans Progressiva.Infertility,Tach Disease ,Epilepsy ,Diabetes ,Coeliac disease,,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma, (measles, tetanus, whooping cough, tuberculosis, polio and diphtheria)Allergic diseases.Parkinson's disease,Schizophrenia,Lung Cancer,Breast Cancer,Colo-Rectal Cancer,Blood Cancer,Prostate Cancer,siva.Fatal Familial Insomnia Factor V Leiden Mutation ,Epilepsy Dupuytren's disease,Desmoplastic small-round-cell tumor Diabetes ,Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
Syndrome Fibrodysplasia Ossificans ProgresSclerosis,Seizures,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpe ,Copd,Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Lung disease.Enlarged prostate,Osteoporosis.
Dementia.,Hiv_ Aids,Herpes,Inflammatory bowel disease ,Copd,Diabetes,Hepatitis
Love Spell,Diabetes.